diff --git a/.bazelrc b/.bazelrc
index 37a0bc114..3b8a91c8c 100644
--- a/.bazelrc
+++ b/.bazelrc
@@ -83,10 +83,16 @@ build:ios_fat --config=ios
 build:ios_fat --ios_multi_cpus=armv7,arm64
 build:ios_fat --watchos_cpus=armv7k
 
+# MacOS configs.
 build:darwin_x86_64 --apple_platform_type=macos
 build:darwin_x86_64 --macos_minimum_os=10.12
 build:darwin_x86_64 --cpu=darwin_x86_64
 
+# MacOS Big Sur with Apple Silicon M1
+build:darwin_arm64 --apple_platform_type=macos
+build:darwin_arm64 --macos_minimum_os=10.16
+build:darwin_arm64 --cpu=darwin_arm64
+
 # This bazelrc file is meant to be written by a setup script.
 try-import %workspace%/.configure.bazelrc
 
diff --git a/.bazelversion b/.bazelversion
index 0b2eb36f5..ee74734aa 100644
--- a/.bazelversion
+++ b/.bazelversion
@@ -1 +1 @@
-3.7.2
+4.1.0
diff --git a/README.md b/README.md
index 8c75978a4..23e0d9981 100644
--- a/README.md
+++ b/README.md
@@ -100,6 +100,71 @@ The source code is hosted in the
 run code search using
 [Google Open Source Code Search](https://cs.opensource.google/mediapipe/mediapipe).
 
+### Build on MacOS
+
+#### CPU: Apple Silicon M1
+1. Build "hello_world":
+```bash
+bazel build -c opt --define MEDIAPIPE_DISABLE_GPU=1 --cpu darwin_arm64 mediapipe/examples/desktop/hello_world:hello_world
+```
+and run:
+```bash
+export GLOG_logtostderr=1
+bazel-bin/mediapipe/examples/desktop/hello_world/hello_world
+```
+2. Build all available examples under mediapipe/examples/desktop:
+```bash
+bash build_macos_desktop_examples.sh --cpu m1 -b
+```
+
+3. Build and run one example app (e.g. mediapipe/examples/desktop/face_detection):
+```
+bash build_macos_desktop_examples.sh --cpu m1 --app face_detection -r
+```
+
+#### CPU: x86_64
+1. Build "hello_world":
+```bash
+bazel build -c opt --define MEDIAPIPE_DISABLE_GPU=1 --cpu darwin_x86_64 mediapipe/examples/desktop/hello_world:hello_world
+```
+and run:
+```bash
+export GLOG_logtostderr=1
+bazel-bin/mediapipe/examples/desktop/hello_world/hello_world
+```
+
+2. Build all available examples under mediapipe/examples/desktop:
+```bash
+bash build_macos_desktop_examples.sh --cpu x86_64 -b
+```
+
+3. Build and run one example app (e.g. mediapipe/examples/desktop/face_detection):
+```
+bash build_macos_desktop_examples.sh --cpu x86_64 --app face_detection -r
+```
+
+#### CPU: i386
+1. Build "hello_world":
+```bash
+bazel build -c opt --define MEDIAPIPE_DISABLE_GPU=1 --cpu darwin_i386 mediapipe/examples/desktop/hello_world:hello_world
+```
+
+and run:
+```bash
+export GLOG_logtostderr=1
+bazel-bin/mediapipe/examples/desktop/hello_world/hello_world
+```
+
+2. Build all available examples under mediapipe/examples/desktop:
+```bash
+bash build_macos_desktop_examples.sh --cpu i386 -b
+```
+
+3. Build and run one example app (e.g. mediapipe/examples/desktop/face_detection):
+```
+bash build_macos_desktop_examples.sh --cpu i386 --app face_detection -r
+```
+
 ## Publications
 
 *   [MediaPipe Holistic - Simultaneous Face, Hand and Pose Prediction, on Device](https://ai.googleblog.com/2020/12/mediapipe-holistic-simultaneous-face.html)
diff --git a/WORKSPACE b/WORKSPACE
index e797410a7..c7cb94346 100644
--- a/WORKSPACE
+++ b/WORKSPACE
@@ -1,5 +1,17 @@
 workspace(name = "mediapipe")
 
+load("@bazel_tools//tools/build_defs/repo:http.bzl", "http_archive")
+http_archive(
+    name = "bazel_skylib",
+    urls = [
+        "https://github.com/bazelbuild/bazel-skylib/releases/download/1.0.3/bazel-skylib-1.0.3.tar.gz",
+        "https://mirror.bazel.build/github.com/bazelbuild/bazel-skylib/releases/download/1.0.3/bazel-skylib-1.0.3.tar.gz",
+    ],
+    sha256 = "1c531376ac7e5a180e0237938a2536de0c54d93f5c278634818e0efc952dd56c",
+)
+load("@bazel_skylib//:workspace.bzl", "bazel_skylib_workspace")
+bazel_skylib_workspace()
+
 load("@bazel_tools//tools/build_defs/repo:http.bzl", "http_archive")
 
 http_archive(
@@ -35,8 +47,8 @@ http_archive(
 
 http_archive(
     name = "rules_cc",
-    strip_prefix = "rules_cc-master",
-    urls = ["https://github.com/bazelbuild/rules_cc/archive/master.zip"],
+    strip_prefix = "rules_cc-main",
+    urls = ["https://github.com/bazelbuild/rules_cc/archive/main.zip"],
 )
 
 http_archive(
diff --git a/mediapipe/BUILD b/mediapipe/BUILD
index 1171ea6f0..55b6e0da1 100644
--- a/mediapipe/BUILD
+++ b/mediapipe/BUILD
@@ -75,7 +75,8 @@ alias(
     actual = select({
         ":macos_i386": ":macos_i386",
         ":macos_x86_64": ":macos_x86_64",
-        "//conditions:default": ":macos_i386",  # Arbitrarily chosen from above.
+        ":macos_arm64": ":macos_arm64",
+        "//conditions:default": ":macos_x86_64",  # Arbitrarily chosen from above.
     }),
     visibility = ["//visibility:public"],
 )
@@ -119,6 +120,15 @@ config_setting(
     visibility = ["//visibility:public"],
 )
 
+config_setting(
+    name = "macos_arm64",
+    values = {
+        "apple_platform_type": "macos",
+        "cpu": "darwin_arm64",
+    },
+    visibility = ["//visibility:public"],
+)
+
 [
     config_setting(
         name = arch,
diff --git a/mediapipe/framework/scheduler_queue.cc b/mediapipe/framework/scheduler_queue.cc
index efad97282..57ee8a936 100644
--- a/mediapipe/framework/scheduler_queue.cc
+++ b/mediapipe/framework/scheduler_queue.cc
@@ -26,7 +26,8 @@
 #include "mediapipe/framework/port/status.h"
 
 #ifdef __APPLE__
-#define AUTORELEASEPOOL @autoreleasepool
+// #define AUTORELEASEPOOL @autoreleasepool
+#define AUTORELEASEPOOL
 #else
 #define AUTORELEASEPOOL
 #endif  // __APPLE__